Although this procedure improved tremor and reduced rigidity, this procedure had little effect on the akinesia associated with PD. Before dopaminergic medications were available, the accepted method of treatment involved surgical placement of a lesion in the ventrolateral thalamus.
Although this procedure improved tremor and reduced rigidity, this procedure had little effect on the akinesia associated with PD. Before dopaminergic medications were available, the accepted method of treatment involved surgical placement of a lesion in the ventrolateral thalamus.Tags: Zoo Business PlanAnatomy Of A Business PlanAt&T Strategic Plan EssayHuck Finn Essay On Racism And SlaveryFilling Station Business PlanSpa Salon Business PlanSmart Words To Use In An EssayEssays Cosi Doug
There is currently no known prevention, cure, or effective treatment for dementia.
Dementia is a specialty section of Frontiers in Neurology that aims to publish significant clinical, translational, and basic research findings on all of aspects of dementia due to neurodegenerative disease.
We welcome papers on cognitive, behavioral, and motor features of dementia.
Papers address the broad spectrum of dementia, including but not limited to the model care of people with dementia, caregiver health and wellbeing, concussion and chronic traumatic encephalopathy, molecular insights into pathological prediction and disease mechanism, biomarkers for diagnosis and progression, potential therapeutics and clinical trials, or the relation between inflammation and neurodegeneration.
Surgical treatment of PD has a long history and a promising future.
Tricyclic antidepressants and electroconvulsive therapy have been used successfully to improve mood and motor disability. Following levodopa administration, symptomatic improvement in movement abnormalities is seen in approximately 60% of patients, and cognitive impairment has also been shown to improve following pharmacotherapy. Levodopa, a dopamine precursor that readily crosses the blood-brain barrier and is metabolized to dopamine, is the most common pharmacologic agent used to treat PD.Dementia, as it is used in this research paper, refers to a persistent decline in intellectual functioning in multiple cognitive domains relative to a previous level of performance. Although Alzheimer’s disease (AD) accounts for 45 to 80% of all dementias, the absence of a definite biological marker of AD in living patients continues to necessitate the exclusion of less common but sometimes treatable dementing conditions and differentiation among degenerative dementias. Approximately 20% of patients with a clinical diagnosis of Alzheimer’s disease are thought to have concomitant diffuse Lewy body disease.Given that some non-Alzheimer’s dementias are potentially treatable (i.e., further cognitive deterioration can be avoided or minimized) and/or reversible (i.e., cognitive functioning can be improved), a thorough consideration of all potential etiologies is imperative. This disease thus appears to reflect an overlap between Parkinson’s disease and Alzheimer’s disease.Dementias due to infectious processes will be reviewed subsequently, many of which may also be treatable if discovered in their early stages. Histologically, Lewy bodies are inclusion bodies (similar to Pick bodies) that disrupt neuronal cytoskeletal organization.Dementia due to toxic or metabolic conditions may be among the most treatable etiologies and are potentially reversible if detected and corrected relatively early. In diffuse Lewy body disease, Lewy bodies are diffusely present in surviving cortical neurons, although they tend to favor layers V and VI of cingulate and entorhinal cortex, and they are also found in the brain stem and substantia nigra.Dementia welcomes submissions of the following article types: Case Report, Clinical Trial, Correction, Editorial, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Specialty Grand Challenge, Study Protocol and Systematic Review.All manuscripts must be submitted directly to the section Dementia, where they are peer-reviewed by the Associate and Review Editors of the specialty section. Executive functioning deficits involving establishing, maintaining, and shifting cognitive set also are common in PD dementia and are similar to deficits in patients with discrete lesions of the frontal lobes. PD is most commonly treated with medication designed to ameliorate the central dopamine deficiency. Deficits in visuospatial abilities involving both visuoperceptual and visuoconstructional aspects have been well documented.