Essays Biochemistry Volume 42

Essays Biochemistry Volume 42-27
Essay Review: Hustlers and Patrons of Science, Millikan's School: A History of the California Institute of Technology, Partners in Science: Foundations and Natural Scientists 1900–1945.

Essay Review: Hustlers and Patrons of Science, Millikan's School: A History of the California Institute of Technology, Partners in Science: Foundations and Natural Scientists 1900–1945.

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The purpose was to investigate whether the content of the polyamines putrescine, spermidine, and spermine, and the activity of the first metabolic key enzyme of polyamine metabolism, ornithine decarboxylase (ODC), represent biochemical markers of malignancy in brain tumours.

METHODS The concentration of putrescine, spermidine, and spermine, and the activity of ODC were biochemically quantified in tissue samples obtained during open microsurgery of 670 patients with brain tumours.

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The author's view of the political economy of modern science will be of interest to historians and social scientists, scientific and medical practitioners, and anyone interested in the ecology of knowledge in scientific institutions and professions.

Science is shaped by its service roles in particular local contexts: This is the central theme. The book shows how biochemistry was defined as a distinct discipline by the programmatic vision of individual biochemists and of patrons and competitors in related disciplines. Drawing extensively on little-used archival sources, the author analyses in detail how biomedical science became a central part of medical training and practice.The present study comprised 670 patients with primary (n=521) and recurrent (n=149) brain tumours surgically treated in the Department of Neurosurgery of the University of Cologne between 19.Informed consent of the patients was obtained according to the Helsinki declaration of ethical requirements. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site.Detailed information on how Wiley uses cookies can be found in our Privacy Policy. The author argues that the priorities and styles of various departments and schools of biochemistry reflect systematic social relationships between that discipline and biology, chemistry and medicine. Chronicle of His Life and Accomplishments in Immunology, Cancer Research, and Chemotherapy1: Paul Ehrlich's Recipe for Success: “Patience, Ability, Money and Luck”. It shows how discipline builders used research programmes as strategies that they adapted to the opportunities offered by changing educational markets and national medical reform movements in the United States, Britain and Germany.Correlation of regional biochemical and histomorphological data in rapidly growing neoplasms showed high enzyme activity in solid tumour parts and low activity in necrotic areas.CONCLUSIONS Novel data relating ODC activation and polyamine concentrations to neuropathology is presented indicating that high ODC activity represents a biochemical marker of malignancy in brain tumours.

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