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In recent years, the diagnosis of MS has increased more rapidly among women, who get the disorder nearly four times more than men.
The reasons are unclear, but the new study is the first to associate a sex difference in the brain with MS.When the researchers tested brain tissue samples obtained from 20 patients after death, they found more S1PR2 in MS patients' brains than in people without the disorder.Brain tissue from females also had higher levels of S1PR2 than male brain tissue.as in example 3 below - see the List of Journals Indexed in Index Medicus). The year of the publication is followed by a semicolon; the volume number and the issue number (in parentheses) are followed by a colon; the initial page number, a hyphen, and the final page number, followed by a period, are set without spaces.When referring to an entire book, not pages or specific sections, use the following format: References should include the last name and first and middle initials of the author(s), italicized title case format for all titles (capitalize all words except prepositions such as Chapters from books should be capitalized in the same format as journal articles (sentence case format) and should not use quotation marks.This barrier normally blocks potentially harmful substances from entering the brain.Opening it up likely allows the inflammatory cells that cause MS to get into the central nervous system. Artemiadis | Christos Bakirtzis | Katerina Zekiou | Timotheos-Stefanos Papadopoulos | Ioannis Diakogiannis | Georgios Hadjigeorgiou | Nikolaos Grigoriadis | Anastasios Orologas Robert H. Tzartos | Georgios Velonakis | Maria Eleftheria Evangelopoulos | Dimitrios Tzanetakos | Katerina Karagiorgou | Georgia Angelopoulou | Dimitrios Kasselimis | Constantin Potagas | Maria Anagnostouli | Leonidas Stefanis | Constantinos Kilidireas Parthena Ifantopoulou | Artemios K. A newly identified difference between the brains of women and men with multiple sclerosis (MS) may help explain why so many more women than men get the disease, researchers at Washington University School of Medicine in St. In recent years, the diagnosis of MS has increased more rapidly among women, who get the disorder nearly four times more than men.The reasons are unclear, but the new study is the first to associate a sex difference in the brain with MS. Studying mice and people, the researchers found that females susceptible to MS produce higher levels of a blood vessel receptor protein, S1PR2, than males and that the protein is present at even higher levels in the brain areas that MS typically damages. ' moment -- our genetic studies led us right to this receptor," said senior author Robyn Klein, MD, Ph D.