Stem Cell Thesis

Furthermore, hippocampal NSCs transplantation can improve the neurological deficits associated with expression of cytokines.

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Pluripotent stem cells (PSCs) are characterised by their ability to self-renew and to differentiate into tissues comprising the three developmental germ layers of the body.

This makes them ideal sources of cells for use in regenerative medicine.

Furthermore, the expression of NT3 in the ts NSCs was higher compared with r NSCs (P Neural stem cells (NSCs) are a type of stem cell that possess self-renewal, self-replication and multi-differentiation properties.

Under certain conditions, NSCs may be induced to differentiate into neurons, astrocytes and oligodendrocytes (1–3).

Some works are not in either database and no count is displayed.

Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.The results demonstrated that, after 5 days of culture, the average number of neurospheres in the cultured ts NSCs was significantly lower compared with r NSCs (P=0.0031).Additionally, compared with the r NSCs, ts NSCs exhibited an enhanced differentiation ability towards neurons.Furthermore, the expression of neurotrophin 3 (NT3), brain‑derived neurotrophic factor (BDNF), glial cell‑derived neurotrophic factor (GDNF) and transforming growth factor (TGF)β1 was also investigated in ts NSCs and r NSCs.The expression of all of the aforementioned proteins was detected using immunofluorescence methods.Nestin was used as a marker to identify the cultured NSCs.Neuronal nuclei protein and glial fibrillary acidic protein (GFAP) were utilized to demonstrate the differentiation of NSCs towards neurons and astrocytes, respectively, in vitro.This is in part likely to be a result of adaptation to the artificial culture environment, known to force cell structural away from the native state, resulting in altered gene expression.The mechanisms by which PSCs, specifically, integrate cues from their physical microenvironment remain largely unexplored.This project aimed to improve the culture environment of PSCs for their enhanced differentiation capacity.It was hypothesised that by altering the physical geometry of the culture substrate, the native PSC structure could be maintained, to improve performance upon differentiation.

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